universe84a

Introduction of Coomb Test  The coomb test is also called the anti-globulin test. Coomb’s test was introduced by Cambridge immunologists Robin Coomb and his et. al. (Arthur Mourant and Rob Race) in 1945. Types of Coomb Test Coomb is of two types- Direct Coomb’s test (DCT) or direct antiglobulin test (DAT) and Indirect Coomb’s test (ICT) or indirect anti-globulin test  (IAT). DCT uses to detect sensitized red blood cells (RBCs) while ICT detects the presence of ‘incomplete’ Rh...

Introduction of Grocott's Hexamine- Silver Borate Stain Grocott's  Hexamine-Silver borate stain is the special staining method of choice for a large majority of histopathology laboratories for the demonstration of all fungi. Principle of Grocott's Hexamine- Silver Borate Stain The exposure of formalin-fixed sections or methanol treated sputum is to chromic acid that reacts with fungal cell wall polysaccharide components to form chromic acid-aldehydes. A hexamine-silver solution at an alkaline pH reduces them and this causes fungal...

Introduction of Anti D Antibody (ADA) Titer Test Anti D Antibody also known as Rh typing antibody and its semi-quantitative determination is titer. ADA titer or Rh antibody titer is clinically significant in a pregnant woman who is Rh-negative and her husband Rh-positive. A rising of ADA titer indicates the possible occurrences, of hemolytic disease of the newborn (HDN). Principle of ADA Titer Test Antibody titration implies a serial dilution of the serum. Each dilution is tested...