Coronavirus is a group of spherical or pleomorphic medium-sized (100-150 nm), enveloped RNA virus, containing pectal or club-shaped peplomers on the surface as shown above picture. Their name coronavirus is due to the crown shape, corona meaning crown. These viruses belong to family Coronaviridiae and there are four genera Alphacoronavirus, Betacoronavirus, Gammacoronavirus and Deltacoronavirus. These viruses infect mammals and birds causing diseases of the respiratory tract, gastrointestinal tract, liver, kidneys, and nervous system while there are seven strains of human coronaviruses:
In November 2002, South China had an outbreak of an unusual respiratory infection, with many deaths. In February 2003, a physician from China visited Hong Kong, fell ill, and died after infecting twelve people. These twelve people went to their countries to fall ill and also initiated outbreaks there. In February in Hanoi, Vietnam, an unusual case of pneumonia was reported by a hospital that sought the help of a WHO office in this connection. Dr. Carlo Urbani, the WHO infectious disease specialist advised for the quarantine but by then outbreaks had involved many countries including the USA, Canada, Ireland, Hong Kong, China, Taiwan, some European countries, and many countries in South East Asia. This new disease was named ‘Severe Acute Respiratory Syndrome(SARS). It affected over 30 countries, with many thousand cases and about 800 deaths. India escaped the SARS outbreak. Dr. Carlo Urbani, who identified this new epidemic participated in its control and died of the disease. A coronavirus was found in the respiratory secretions of these patients by electron microscopy and confirmed by growth in Vero cell culture, cloning, sequencing, and animal inoculation. This coronavirus appeared to be a new virus different from other coronaviruses and this strain is SARS-CoV.
In September 2012, a new type of coronavirus was identified, initially called Novel Coronavirus 2012, and now officially named Middle East respiratory syndrome coronavirus (MERS-CoV). The World Health Organization issued a global alert soon after. The WHO update on 28 September 2012 stated that the virus did not seem to pass easily from person to person. However, on 12 May 2013, a case of human-to-human transmission in France was confirmed by the French Ministry of Social Affairs and Health. In addition, cases of human-to-human transmission have been reported by the Ministry of Health in Tunisia. Two confirmed cases involved people who seemed to have caught the disease from their late father, who became ill after a visit to Qatar and Saudi Arabia. Despite this, it appears that the virus has trouble spreading from human to human, as most individuals who are infected do not transmit the virus. By 30 October 2013, there were 124 cases and 52 deaths in Saudi Arabia. After the Dutch Erasmus Medical Centre sequenced the virus, the virus was given a new name, Human Coronavirus–Erasmus Medical Centre (HCoV-EMC). The final name for the virus is Middle East respiratory syndrome coronavirus (MERS-CoV). In May 2014, only two United States cases of MERS-CoV infection were recorded, both occurring in healthcare workers who worked in Saudi Arabia and then traveled to the U.S. One was treated in Indiana and one in Florida. Both of these individuals were hospitalized temporarily and then discharged. In May 2015, an outbreak of MERS-CoV occurred in the Republic of Korea, when a man who had traveled to the Middle East, visited 4 different hospitals in the Seoul area to treat his illness. This caused one of the largest outbreaks of MERS-CoV outside of the Middle East. As of December 2019, 2,468 cases of MERS-CoV infection had been confirmed by laboratory tests, 851 of which were fatal, a mortality rate of approximately 34.5%.
In December 2019, a pneumonia outbreak was reported in Wuhan, China. On 31 December 2019, the outbreak was traced to a novel strain of coronavirus, which was labeled as 2019-nCoV by the World Health Organization (WHO). According to Daniel Lucey at Georgetown University, the first human infections must have occurred in November 2019 or earlier. As of 30 January 2020, there have been 214 confirmed deaths and more than 8,230 confirmed cases in the coronavirus pneumonia outbreak. The Wuhan strain has been identified as a new strain of Betacoronavirus from group 2B with an ~70% genetic similarity to the SARS-CoV. The virus was suspected to have originated in snakes, but many leading researchers disagree with this conclusion. Daniel Lucey, an infectious disease specialist at Georgetown University, stated that “Now it seems clear that the seafood market is not the only origin of the virus”. Now in detail about
Coughs or sneezes from infected persons or touching contaminated objects.
Symptoms are divided into common and severe symptoms.
Common symptoms include-
while severe symptoms include-
There is lacking proper antiviral drugs and vaccines and therefore, no specific treatment or prophylaxis is available. The virus is highly mutable, hence the vaccine may not be easy to prepare however preparation in the trial. In this period, strict isolation and quarantine are the only ways to control the disease.
Novel coronavirus has just been declared a public health emergency of international concern by the World Health Organization (WHO). Here are few ways to protect yourself, your children, and your community: